Cartilage oligomeric matrix protein

Available structures
PDBOrtholog search: PDBe RCSB
Aliases COMP, EDM1, EPD1, MED, PSACH, THBS5, cartilage oligomeric matrix protein
External IDs OMIM: 600310 MGI: 88469 HomoloGene: 74 GeneCards: COMP
RNA expression pattern
More reference expression data
Species Human Mouse









RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 19: 18.78 – 18.79 Mb Chr 8: 70.37 – 70.38 Mb
PubMed search [1] [2]
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Cartilage oligomeric matrix protein (COMP), also known as thrombospondin-5, is an extracellular matrix (ECM) protein primarily present in cartilage. In humans it is encoded by the COMP gene.[3][4][5]


The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein.[6] It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfide bonds. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).[5]

COMP is a marker of cartilage turnover.[7] It is present in high quantities in fibrotic scars and systemic sclerosis, and it appears to have a role in vascular wall remodeling.[8]


  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Newton G, Weremowicz S, Morton CC, Copeland NG, Gilbert DJ, Jenkins NA, Lawler J (Dec 1994). "Characterization of human and mouse cartilage oligomeric matrix protein". Genomics. 24 (3): 435–9. doi:10.1006/geno.1994.1649. PMID 7713493.
  4. Briggs MD, Rasmussen IM, Weber JL, Yuen J, Reinker K, Garber AP, Rimoin DL, Cohn DH (Dec 1993). "Genetic linkage of mild pseudoachondroplasia (PSACH) to markers in the pericentromeric region of chromosome 19". Genomics. 18 (3): 656–60. doi:10.1016/S0888-7543(05)80369-6. PMID 8307576.
  5. 1 2 "Entrez Gene: COMP cartilage oligomeric matrix protein".
  6. Paulsson M, Heinegård D (Aug 1981). "Purification and structural characterization of a cartilage matrix protein". The Biochemical Journal. 197 (2): 367–75. doi:10.1042/bj1970367. PMC 1163135Freely accessible. PMID 7325960.
  7. Petersen SG, Saxne T, Heinegard D, Hansen M, Holm L, Koskinen S, Stordal C, Christensen H, Aagaard P, Kjaer M (Jan 2010). "Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training". Osteoarthritis and Cartilage / OARS, Osteoarthritis Research Society. 18 (1): 34–40. doi:10.1016/j.joca.2009.07.004. PMID 19679221.
  8. Halper J, Kjaer M (2014). "Basic components of connective tissues and extracellular matrix: elastin, fibrillin, fibulins, fibrinogen, fibronectin, laminin, tenascins and thrombospondins". Advances in Experimental Medicine and Biology. 802: 31–47. doi:10.1007/978-94-007-7893-1_3. PMID 24443019.

Further reading

External links

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