Charles David Allis

Charles David Allis

Born	(1951-03-22)March 22, 1951
Fields	epigenetics
Institutions	Rockefeller University 2003-present University of Virginia 1998-2003 University of Rochester 1995-1998 Baylor College of Medicine 1981-1990
Alma mater	University of Cincinnati Indiana University

Charles David Allis (born March 22, 1951) is an American molecular biologist, and is currently the Joy and Jack Fishman Professor and Head of the Laboratory of Chromatin Biology and Epigenetics at The Rockefeller University. In pursuit of understanding the DNA-histone protein complex and the intricate system which allows for gene activation, the Allis lab focuses on chromatin signaling via histone modifications - acetylation, methylation and phosphorylation. Allis is best known for deciphering regulatory mechanisms that impinge upon the fundamental repeating unit of chromatin and for identifying the responsible enzyme systems that govern the covalent modifications of histone proteins, the principal components that organize chromatin. Allis discovered the critical link, through histone acetyltransferase-containing transcriptional coactivators, between targeted histone acetylation and gene-specific transcriptional activation. In further studies, he linked histone phosphorylation events to mitosis and mitogen action, established a synergy between histone phosphorylation and acetylation events and elaborated the ‘histone code hypothesis’ (and extensions thereof), one of the most highly cited theories governing epigenetics.

Education

University of Cincinnati, B.S., summa cum laude, Biology, 1973
Indiana University, Ph.D., Biology, 1978, "Isolation and characterization of pole cells and polar granules from Drosophila melanogaster,"
University of Rochester, Postdoctoral fellowship, 1978-1981

Honors & Awards

Phi Beta Kappa
2001: Election to the American Academy of Arts and Sciences
2001: DeWitt Stetten Jr. Award Recipient, sponsored by the Institute of General Medical Sciences, NIH
2002: Dickson Prize in Medicine at the University of Pittsburgh School of Medicine
2003: Massry Prize in Chromatin and Transcription (shared with Drs. Michael Grunstein and Roger Kornberg)
2004: Wiley Prize for Distinguished Research in the Biomedical Sciences
2005: Elected to the National Academy of Sciences,
2007: Distinguished Alumnus Award, University of Cincinnati
2007: Gairdner Foundation International Award
2008: ASBMB-Merck Award for Distinguished Research in the Biomedical Sciences
2011: Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research (shared with Dr. Michael Grunstein), Brandeis University
2011: Howard T. Ricketts Prize for Distinguished Research in the Biomedical Sciences, University of Chicago
2013: Nicholson Award Lecturer at the Karolinska Institutet, Stockholm, Sweden
2014: Japan Prize^[1]
2014: Charles-Léopold Mayer Prize of the Académie des Sciences, France
2015: Breakthrough Prize in Life Sciences
2016: Gruber Prize in Genetics from the Rockefeller Foundation (jointly with Michael Grunstein) ^[2]

Notes

↑ Philippidis 2014
↑ http://gruber.yale.edu/prize/2016-gruber-genetics-prize

References

Philippidis, Alex (2014). "Rockefeller Professor Wins Japan Prize". Gen. Eng. Biotechnol. News (paper). 34 (4): 7. ...for the pioneering work of his lab in discovering that chemical modifications of DNA-packaging proteins play a key role in regulating the activity of individual genes.

External links

Breakthrough Prize laureates

Fundamental Physics	Nima Arkani-Hamed, Alan Guth, Alexei Kitaev, Maxim Kontsevich, Andrei Linde, Juan Maldacena, Nathan Seiberg, Ashoke Sen, Edward Witten (2012) Special: Stephen Hawking, Peter Jenni, Fabiola Gianotti (ATLAS), Michel Della Negra, Tejinder Virdee, Guido Tonelli, Joseph Incandela (CMS) and Lyn Evans (LHC) (2013) Alexander Polyakov (2013) Michael Green and John Henry Schwarz (2014) Saul Perlmutter and members of the Supernova Cosmology Project; Brian Schmidt, Adam Riess and members of the High-Z Supernova Team (2015) Special: Ronald Drever, Kip Thorne, Rainer Weiss and contributors to LIGO project (2016) Yifang Wang and Kam-Biu Luk and the Daya Bay team, Atsuto Suzuki and the KamLAND team, Koichiro Nishikawa and the K2K / T2K team, Arthur B. McDonald and the Sudbury Neutrino Observatory team, Takaaki Kajita and Yoichiro Suzuki and the Super-Kamiokande team (2016)

Life sciences	Cornelia Bargmann, David Botstein, Lewis C. Cantley, Hans Clevers, Titia de Lange, Napoleone Ferrara, Eric Lander, Charles Sawyers, Robert Weinberg, Shinya Yamanaka and Bert Vogelstein (2013) James P. Allison, Mahlon DeLong, Michael N. Hall, Robert S. Langer, Richard P. Lifton and Alexander Varshavsky (2014) Alim-Louis Benabid, Charles David Allis, Victor Ambros, Gary Ruvkun, Jennifer Doudna and Emmanuelle Charpentier (2015) Edward Boyden, Karl Deisseroth, John Hardy, Helen Hobbs and Svante Pääbo (2016) Stephen J. Elledge, Harry F. Noller, Roeland Nusse, Yoshinori Ohsumi, Huda Zoghbi (2017)

Mathematics	Simon Donaldson, Maxim Kontsevich, Jacob Lurie, Terence Tao and Richard Taylor (2015) Ian Agol (2016) Jean Bourgain (2017)

Authority control	WorldCat Identities VIAF: 85250400

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