| Other names
|3D model (Jmol)||Interactive image|
|Molar mass||355.52 g·mol−1|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Azastene is a chemical that modulates 3β-hydroxysteroid dehydrogenase activity.
One synthesis of this compound involves initial alkylation of methyl testosterone by means of strong base and methyl iodide to afford the 4,4-dimethyl derivative. Formylation with alkoxide and methyl formate leads to the 2-hydroxymethyl derivative. Reaction of this last with hydroxylamine leads to formation of an isoxazole ring. There is then obtained azastene.
- Liu, CG; Dai, MZ; Li, WK; Liu, GM; Lin, ZM; Ma, RH (1987). "Interceptive action of azastene and its effects on plasma progesterone in pregnant rats and rabbits". Zhongguo yao li xue bao = Acta pharmacologica Sinica. 8 (6): 540–3. PMID 3451668.
- Gordon O. Potts, Sterling Drug Inc. U.S. Patent 3,966,926 (1976).