"Autoschizis" is a term derived from the Greek αὐτο- auto-, meaning "self", and σχίζειν skhizein, "to split". It was introduced in 1998[1] to describe a novel form of cancer cell death characterized by a reduction in cell size that occurs due to the loss of cytoplasm through self-excision (the cell splits open) without the loss of cell organelles, morphologic degradation of the cells nucleus and nucleolus without the formation of apoptotic bodies and destruction of the cell membrane. The cell death results from karyorrhexis and karyolysis.[2] Autoschizis can be initiated via in vivo treatment with vitamin C (VC), synthetic vitamin K (VK3) or, better, a combination of both. The treatment has been tested on various types of cancer cells in vitro and in vivo with positive results.[3]


  1. Gilloteaux, J; Jamison, JM; Arnold, D; Ervin, E; Eckroat, L; Docherty, JJ; Neal, D; Summers, JL (1998). "Cancer cell necrosis by autoschizis: Synergism of antitumor activity of vitamin C: Vitamin K3 on human bladder carcinoma T24 cells". Scanning. 20 (8): 564–75. doi:10.1002/sca.4950200805. PMID 9891940.
  2. Jamison, James M.; Gilloteaux, Jacques; Taper, Henryk S.; Calderon, Pedro Buc; Summers, Jack L. (2002). "Autoschizis: a novel cell death". Biochem. Pharmacol. 63 (10): 1773–83. doi:10.1016/S0006-2952(02)00904-8. PMID 12034362.
  3. Gilloteaux, J; Jamison, JM; Arnold, D; Jarjoura, D; Von Greuningen, V; Summers, JL (2003). "Autoschizis of human ovarian carcinoma cells: Scanning electron and light microscopy of a new cell death induced by sodium ascorbate: Menadione treatment". Scanning. 25 (3): 137–49. doi:10.1002/sca.4950250306. PMID 12866647.


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