Atraric acid

Atraric acid
IUPAC name
Methyl 2,4-dihydroxy-3,6-dimethylbenzoate
Molar mass 196.20 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Atraric Acid is a naturally occurring phenolic compound and ester with the IUPAC name methyl 2,4-dihydroxy-3,6-dimethylbenzoate and molecular formula C10H12O4.[1] It occurs in the root-bark of Pygeum africanum[2] and Evernia prunastri (Oakmoss). There is evidence to suggest that it has anti-androgenic activity in human beings[2] and use in treatment for benign prostate hyperplasia, prostate cancer and spinal and bulbar muscular atrophy have been investigated.[1]


  1. 1 2 US application 20090143466, Aria Baniahmad; Hans-Rainer Hoffmann & Rudolf Matusch, "Isolation of Atraric Acid, Synthesis of Atraric Acid Derivatives, and Use of Atraric Acid and the Derivatives Thereof for the Treatment of Benign Prostatic Hyperplasia, Prostate Carcinoma and Spinobulbar Muscular Atrophy", published 2009-06-04, assigned to Aria Baniahmad and Hans-Rainer Hoffmann
  2. 1 2 Buss, Antony; Mark Butler (2010). Natural Product Chemistry for Drug Discovery. Royal Society of Chemistry. pp. 145, 146. ISBN 978-0-85404-193-0.

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