Clinical data
AHFS/Drugs.com International Drug Names
ATC code C01BB04 (WHO)
CAS Number 37640-71-4 YesY
PubChem (CID) 2218
DrugBank DB01429 YesY
ChemSpider 2132 YesY
UNII 5Y48085P9Q YesY
KEGG D02969 YesY
Chemical and physical data
Formula C22H30N2
Molar mass 322.487 g/mol
3D model (Jmol) Interactive image

Aprindine is a Class 1b antiarrhythmic agent.[1]

In one study, it delayed atrial fibrillation more than digoxin did.[2]

It has shown effectiveness when given orally.[3]


  1. Sato R, Hisatome I, Tanaka Y, et al. (September 1991). "Aprindine blocks the sodium current in guinea-pig ventricular myocytes". Naunyn Schmiedebergs Arch. Pharmacol. 344 (3): 331–6. doi:10.1007/bf00183008. PMID 1660104.
  2. Atarashi H, Inoue H, Fukunami M, Sugi K, Hamada C, Origasa H (June 2002). "Double-blind placebo-controlled trial of aprindine and digoxin for the prevention of symptomatic atrial fibrillation". Circ. J. 66 (6): 553–6. doi:10.1253/circj.66.553. PMID 12074271.
  3. Reid PR, Greene HL, Varghese PJ (December 1977). "Suppression of refractory arrhythmias by aprindine in patients with the Wolff-Parkinson-White syndrome". Br Heart J. 39 (12): 1353–60. doi:10.1136/hrt.39.12.1353. PMC 483421Freely accessible. PMID 603737.
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