Andreas Matouschek

Andreas Matouschek
Born Germany
Residence USA
Citizenship American
Fields Biochemistry
Institutions Northwestern University
Alma mater Cambridge University
Doctoral advisor Alan Fersht
Known for Protein Unfolding

Andreas Matouschek is a biologist at Northwestern University, where he is professor of biochemistry, molecular biology, and cell biology in the Weinberg College of Arts and Sciences.[1] His graduate work with Alan Fersht resulted in the seminal application of phi-value analysis to the study of barnase, a bacterial RNAse used in many protein folding studies.[2] Development of phi value analysis in combination with extensive protein engineering enabled an understanding of the kinetic intermediates during protein folding of barnase. In subsequent postdoctoral work at the University of Basel, he applied the protein engineering approach to studying unfolding of proteins as they pass through mitochondrial translocons (TIM/TOM Complex).

Matouschek currently studies the proteasome, the degradation machinery of eukaryotic cells, and the mechanisms by which the proteasome is able to unfold and translocate proteins.[3]

In 2012, Matouschek moved to the University of Texas at Austin where he is continuing biochemical and cell biological studies of the proteasome.


  1. The Matouschek Lab
  2. Matouschek, Andreas; Kellis, James T.; Serrano, Luis; Bycroft, Mark; Fersht, Alan R. (1990). "Transient folding intermediates characterized by protein engineering". Nature. 346 (6283): 440–5. doi:10.1038/346440a0. PMID 2377205.
  3. Schrader, Erin K; Harstad, Kristine G; Matouschek, Andreas (2009). "Targeting proteins for degradation". Nature Chemical Biology. 5 (11): 815–22. doi:10.1038/nchembio.250. PMC 4228941Freely accessible. PMID 19841631.

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