Protein metabolism

Protein metabolism denotes the various biochemical processes responsible for the synthesis of proteins and amino acids, and the breakdown of proteins (and other large molecules, too) by catabolism.

Dietary proteins are first broken down to individual amino acids by various enzymes and hydrochloric acid present in the gastro-intestinal tract.[1] These amino acids are further broken down to α-keto acids which can be recycled in the body for generation of energy, and production of glucose or fat or other amino acids. This break-down of amino acids to α-keto acids occurs in the liver by a process known as transamination, which follows a bimolecular ping pong mechanism.[2]

Protein synthesis

Main article: Protein biosynthesis

Protein biosynthesis relies on four processes:

Protein anabolism is the process by which protein are formed from amino acids (aka anabolic amino acid synthesis).

Protein breakdown

Main article: Proteolysis

Protein catabolism is the process by which proteins are broken down to their amino acids. This is also called proteolysis.

This can be followed by further amino acid degradation.

Amino acid metabolism

The following list contains links to information about the metabolism of individual amino acids.


  1. Mehta, S. Digestion of Dietary Proteins
  2. Mehta, S. Metabolism of amino acids- bimolecular ping pong mechanism of transamination.

This article is issued from Wikipedia - version of the 10/23/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.