Alpha cell

Alpha cell

Pancreatic islets (islets of Langerhans).
Code TH H3.

Anatomical terminology

Alpha cells (more commonly alpha-cells or α-cells) are endocrine cells in the pancreatic islets of the pancreas. They make up to 20% of the human islet cells synthesizing and secreting the peptide hormone glucagon, which elevates the glucose levels in the blood.[1]


To elevate glucose levels, glucagon binds to receptors on hepatocytes (liver cells) and some other cells (e.g. kidney cells). This activates an enzyme, glycogen phosphorylase, inside the hepatocyte to hydrolyse glycogen to glucose. This process is called glycogenolysis. In rodents, alpha cells are located in the periphery of the islets, however in humans the islet architecture is generally less organized and alpha cells are frequently observed inside the islets as well. When being viewed by an electron microscope, alpha cells can be identified by their characteristic granules with a large dense core and a small white halo.

See also

External links


  1. Kerr, J B (2000). Atlas of functional histology. Uk: Mosby. p. 309. ISBN 0-7234-3072-1.

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