Allotype (immunology)

The allotype affects the constant region (labeled CL and CH1-3 in the diagram.)

In immunology, an immunoglobulin allotype is the allele of the antibody chains found in the individual. The word allotype comes from two Greek roots, allo meaning 'other or differing from the norm' and typos meaning 'mark.' Thus allotype refers to the idea that each immunoglobin has unique sequences particular to the individual's genome that manifest in its constant region (normally).

The most important types are Gm (heavy chain) and km (light chain).

It can be used in resolving paternity disputes.[1]

See also


External links

This article is issued from Wikipedia - version of the 5/1/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.