Clinical data
Pronunciation ay-FOX-oh-LAN-ər
Trade names NexGard
Routes of
By mouth (chewables)
ATCvet code QP53BE01 (WHO)
Legal status
Legal status
Pharmacokinetic data
Bioavailability 74% (Tmax = 2–4 hours)[1]
Biological half-life 14 hours[1]
Excretion Biliary (major route)
Synonyms 4-[(5RS)-5-(5-Chloro-α,α,α-trifluoro-m-tolyl)-4,5-dihydro-5-(trifluoromethyl)-1,2-oxazol-3-yl]-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]naphthalene-1-carboxamide
CAS Number 1093861-60-9
PubChem (CID) 25154249
ChemSpider 28651525
KEGG D10361
Chemical and physical data
Formula C26H17ClF9N3O3
Molar mass 625.88 g·mol−1
3D model (Jmol) Interactive image
Chirality Racemic mixture

Afoxolaner (INN)[2] is an insecticide and acaricide used in dogs. It is indicated for the treatment and prevention of flea infestations, and the treatment and control of tick infestations in dogs and puppies 8 weeks of age and older, weighing 4 pounds (~1.8 kilograms) of body weight or greater. It is given once a month.[3]

Unlike most other flea treatments which are applied topically to the animal's coat, afoxolaner is administered orally in meat-flavoured tablets, and poisons fleas once they start feeding. It is used either alone or as a combination treatment with milbemycin oxime.[4][5][6]

See also


  1. 1 2 3 "Frontline NexGard (afoxolaner) for the Treatment and Prophylaxis of Ectoparasitic Diseases in Dogs. Full Prescribing Information" (PDF) (in Russian). Sanofi Russia. Retrieved 14 November 2016.
  2. "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names: List 70" (PDF). World Health Organization. pp. 276–7. Retrieved 14 November 2016.
  3. "NexGard (afoxolaner) Chewables. Full Prescribing Information" (PDF). Frontline Vet Labs, a Division of Merial, Inc. Duluth, GA 30096-4640 USA. Retrieved 14 November 2016.
  4. Shoop, WL; Hartline, EJ; Gould, BR; Waddell, ME; McDowell, RG; Kinney, JB; Lahm, GP; Long, JK; Xu, M; Wagerle, T; Jones, GS; Dietrich, RF; Cordova, D; Schroeder, ME; Rhoades, DF; Benner, EA; Confalone, PN (2 April 2014). "Discovery and Mode of Action of Afoxolaner, a New Isoxazoline Parasiticide for Dogs" (PDF). Veterinary Parasitology. 201 (3-4): 179–89. doi:10.1016/j.vetpar.2014.02.020. PMID 24631502. Retrieved 14 November 2016.
  5. Beugnet, F; deVos, C; Liebenberg, J; Halos, L; Fourie, J (25 August 2014). "Afoxolaner Against Fleas: Immediate Efficacy and Resultant Mortality After Short Exposure on Dogs" (PDF). Parasite. 21: 42. doi:10.1051/parasite/2014045. PMC 4141545Freely accessible. PMID 25148564. Retrieved 14 November 2016.
  6. Beugnet, F; Crafford, D; de Vos, C; Kok, D; Larsen, D; Fourie, J (15 August 2016). "Evaluation of the Efficacy of Monthly Oral Administration of Afoxolaner plus Milbemycin Oxime (NexGard Spectra®, Merial) in the Prevention of Adult Spirocerca lupi Establishment in Experimentally Infected Dogs" (PDF). Veterinary Parasitology. 226: 150–61. doi:10.1016/j.vetpar.2016.07.002. PMID 27514901. Retrieved 14 November 2016.
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