S-adenosylhomocysteine hydrolase

SAH hydrolase tetramer, Human
Symbol AHCY
Entrez 191
HUGO 343
OMIM 180960
RefSeq NM_000687
UniProt P23526
Other data
EC number
Locus Chr. 20 q11.22

Adenosylhomocysteinase (EC, S-adenosylhomocysteine synthase, S-adenosylhomocysteine hydrolase, adenosylhomocysteine hydrolase, S-adenosylhomocysteinase, SAHase, AdoHcyase) is an enzyme that converts S-adenosylhomocysteine to homocysteine and adenosine.[1][2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-homocysteine + H2O L-homocysteine + adenosine

The enzyme contains one tightly bound NAD+ per subunit.


  1. de la Haba, G.; Cantoni, G.L. (1959). "The enzymatic synthesis of S-adenosyl-L-homocysteine from adenosine and homocysteine". J. Biol. Chem. 234: 603–608. PMID 13641268.
  2. Palmer, J.L.; Abeles, R.H. (1979). "The mechanism of action of S-adenosylhomocysteinase". J. Biol. Chem. 254: 1217–1226. PMID 762125.

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