Acetophenone carboxylase

Acetophenone carboxylase (EC 6.4.1.8) is an enzyme with systematic name acetophenone:carbon-dioxide ligase (ADP-forming).^[1] This enzyme catalyses the following chemical reaction

2 ATP + acetophenone + HCO₃⁻ + H₂O + H⁺

\rightleftharpoons

2 ADP + 2 phosphate + 3-oxo-3-phenylpropanoate

The enzyme is involved in anaerobic degradation of ethylbenzene.

References

↑ Jobst, B.; Schuhle, K.; Linne, U.; Heider, J. (2010). "ATP-dependent carboxylation of acetophenone by a novel type of carboxylase". J. Bacteriol. 192: 1387–1394. doi:10.1128/jb.01423-09. PMID 20047908.

Ligases: carbon-carbon ligases (EC 6.4)

Biotin dependent carboxylation	Pyruvate carboxylase Acetyl-CoA carboxylase Propionyl-CoA carboxylase Methylcrotonyl-CoA carboxylase

Other	Polyketide synthase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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