ATP11C is an enzyme that in humans is encoded by the ATP11C gene.


ATP11C encodes a member of the Type IV P-type ATPase family that is thought to transport or 'flip' aminophospholipids. The corresponding protein in mice is essential for the development of B cells and red blood cells,[1][2] and for the prevention of intrahepatic cholestasis.[3]


  1. Siggs, O.M., Arnold, C.N., Huber, C., Pirie, E., Xia, Y., Lin, P., Nemazee, D., and Beutler, B. (2011). The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow. Nat Immunol 12, 434–440.
  2. Yabas, M., Teh, C.E., Frankenreiter, S., Lal, D., Roots, C.M., Whittle, B., Andrews, D.T., Zhang, Y., Teoh, N.C., Sprent, J., et al. (2011). ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes. Nat Immunol.
  3. Siggs, O.M., Schnabl, B., Webb, B., and Beutler, B. (2011). X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C. Proc Natl Acad Sci USA 108, 7890–7895.

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