ALPPL2
| ALPPL2 | |||||||||||||||||
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| Identifiers | |||||||||||||||||
| Aliases | ALPPL2, ALPG, ALPPL, GCAP, alkaline phosphatase, placental like 2 | ||||||||||||||||
| External IDs | MGI: 108009 HomoloGene: 129600 GeneCards: ALPPL2 | ||||||||||||||||
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| Orthologs | |||||||||||||||||
| Species | Human | Mouse | |||||||||||||||
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| RefSeq (protein) | |||||||||||||||||
| Location (UCSC) | Chr 2: 232.41 – 232.41 Mb | Chr 1: 87.09 – 87.09 Mb | |||||||||||||||
| PubMed search | [1] | [2] | |||||||||||||||
| Wikidata | |||||||||||||||||
| View/Edit Human | View/Edit Mouse |
Alkaline phosphatase, placental-like 2 is a protein that in humans is encoded by the ALPPL2 gene.[3]
Function
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme, localized to testis, thymus and certain germ cell tumors, that is closely related to both the placental and intestinal forms of alkaline phosphatase.[3]
References
Further reading
- Shigenari, A.; Ando, A.; Baba, T.; Yamamoto, T.; Katsuoka, Y.; Inoko, H. (1998). "Characterization of alkaline phosphatase genes expressed in seminoma by cDNA cloning". Cancer Research. 58 (22): 5079–5082. PMID 9823315.
- Henthorn, P. S.; Knoll, B. J.; Raducha, M.; Rothblum, K. N.; Slaughter, C.; Weiss, M.; Lafferty, M. A.; Fischer, T.; Harris, H. (1986). "Products of two common alleles at the locus for human placental alkaline phosphatase differ by seven amino acids". Proceedings of the National Academy of Sciences of the United States of America. 83 (15): 5597–5601. doi:10.1073/pnas.83.15.5597. PMC 386335
. PMID 3461452. - Jemmerson, R.; Shah, N.; Takeya, M.; Fishman, W. H. (1985). "Characterization of the placental alkaline phosphatase-like (Nagao) isozyme on the surface of A431 human epidermoid carcinoma cells". Cancer Research. 45 (1): 282–287. PMID 2578098.
- Shen, L. P.; Liu, H.; Kan, Y. W.; Kam, W. (1988). "5' nucleotide sequence of a putative human placental alkaline phosphatase-like gene". Nucleic Acids Research. 16 (12): 5694. doi:10.1093/nar/16.12.5694. PMC 336801. PMID 3387245.
- Lowe, M. E. (1992). "Site-specific mutations in the COOH-terminus of placental alkaline phosphatase: A single amino acid change converts a phosphatidylinositol-glycan-anchored protein to a secreted protein". The Journal of Cell Biology. 116 (3): 799–807. doi:10.1083/jcb.116.3.799. PMC 2289307. PMID 1730777.
- Le Du, M. H.; Stigbrand, T.; Taussig, M. J.; Menez, A.; Stura, E. A. (2000). "Crystal Structure of Alkaline Phosphatase from Human Placenta at 1.8 a Resolution. IMPLICATION FOR a SUBSTRATE SPECIFICITY". Journal of Biological Chemistry. 276 (12): 9158–9165. doi:10.1074/jbc.M009250200. PMID 11124260.
- Fisken, J.; Leonard, R. C.; Shaw, G.; Bowman, A.; Roulston, J. E. (1989). "Serum placental-like alkaline phosphatase (PLAP): A novel combined enzyme linked immunoassay for monitoring ovarian cancer". Journal of clinical pathology. 42 (1): 40–45. doi:10.1136/jcp.42.1.40. PMC 1141788. PMID 2921344.
- Ben-Arie, A.; Hagay, Z.; Ben-Hur, H.; Open, M.; Dgani, R. (1999). "Elevated serum alkaline phosphatase may enable early diagnosis of ovarian cancer". European journal of obstetrics, gynecology, and reproductive biology. 86 (1): 69–71. doi:10.1016/S0301-2115(99)00054-8. PMID 10471145.
- Goldstein, D. J.; Rogers, C.; Harris, H. (1982). "A search for trace expression of placental-like alkaline phosphatase in non-malignant human tissues: Demonstration of its occurrence in lung, cervix, testis and thymus". Clinica chimica acta; international journal of clinical chemistry. 125 (1): 63–75. doi:10.1016/0009-8981(82)90046-8. PMID 6814793.
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