Clinical data
ATC code None
CAS Number 137502-84-2
PubChem (CID) 676310
ChemSpider 589045
Chemical and physical data
Formula C15H10O5
Molar mass 270.2369 g/mol
3D model (Jmol) Interactive image

7,8,3′-Trihydroxyflavone (7,8,3'-THF) is a flavone and small-molecule agonist of TrkB, the main receptor of brain-derived neurotrophic factor (BDNF), that was derived from 7,8-dihydroxyflavone (7,8-DHF).[1][2] Relative to 7,8-DHF, 7,8,3'-THF is 2–3-fold more potent in vitro as a TrkB agonist.[1][2] 7,3’-Dihydroxyflavone (7,3'-DHF) is also more potent than 7,8-DHF in vitro, indicating that a 3'-hydroxy group on the B-ring enhances TrkB agonistic activity.[1] 7,8,3'-THF has been tested in vivo and was found to produce TrkB-dependent neuroprotective effects in mice similarly to 7,8-DHF.[2][3]

See also


  1. 1 2 3 Liu, Xia; Chan, Chi-Bun; Jang, Sung-Wuk; Pradoldej, Sompol; Huang, Junjian; He, Kunyan; Phun, Lien H.; France, Stefan; Xiao, Ge; Jia, Yonghui; Luo, Hongbo R.; Ye, Keqiang (2010). "A Synthetic 7,8-Dihydroxyflavone Derivative Promotes Neurogenesis and Exhibits Potent Antidepressant Effect". Journal of Medicinal Chemistry. 53 (23): 8274–8286. doi:10.1021/jm101206p. ISSN 0022-2623.
  2. 1 2 3 Yu, Qing; Chang, Qing; Liu, Xia; Gong, Shusheng; Ye, Keqiang; Lin, Xi (2012). "7,8,3′-Trihydroxyflavone, a potent small molecule TrkB receptor agonist, protects spiral ganglion neurons from degeneration both in vitro and in vivo". Biochemical and Biophysical Research Communications. 422 (3): 387–392. doi:10.1016/j.bbrc.2012.04.154. ISSN 0006-291X.
  3. Yu, Q.; Chang, Q.; Liu, X.; Wang, Y.; Li, H.; Gong, S.; Ye, K.; Lin, X. (2013). "Protection of Spiral Ganglion Neurons from Degeneration Using Small-Molecule TrkB Receptor Agonists". Journal of Neuroscience. 33 (32): 13042–13052. doi:10.1523/JNEUROSCI.0854-13.2013. ISSN 0270-6474.

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