|Chemical and physical data|
|Molar mass||259.385 g/mol|
|3D model (Jmol)||Interactive image|
4'-Methyl-α-pyrrolidinohexiophenone or MPHP is a stimulant compound which has been reported as a novel designer drug. It is closely related to pyrovalerone, being simply its chain-lengthened homologue. In the pyrrolidinophenone series, stimulant activity is maintained so long as the positions of the aryl, ketone and pyrrolidinyl groups are held constant, while the alkyl backbone can be varied anywhere between three and as many as seven carbons, with highest potency usually seen with the pentyl or isohexyl backbone, and a variety of substituents are tolerated on the aromatic ring.
In 2010 a group of researchers from the Institute of Forensic Medicine, University Hospital Jena, Germany concluded that MPHP can lead to serious poisoning with toxic liver damage and rhabdomyolysis.
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- Peters, FT; Dragan, CA; Kauffels, A; Schwaninger, AE; Zapp, J; Bureik, M; Maurer, HH (2009). "Biotechnological synthesis of the designer drug metabolite 4'-hydroxymethyl-alpha-pyrrolidinohexanophenone in fission yeast heterologously expressing human cytochrome P450 2D6--a versatile alternative to multistep chemical synthesis". Journal of analytical toxicology. 33 (4): 190–7. doi:10.1093/jat/33.4.190. PMID 19470220.
- "Acute poisoning involving the pyrrolidinophenone-type designer drug 4'-methyl-alpha-pyrrolidinohexanophenone (MPHP)". Forensic Sci. Int. 208 (1-3): e20–5. May 2011. doi:10.1016/j.forsciint.2011.02.026. PMID 21444164.
- GB patent 1149366, "α-substituted-ketones and processes for their preparation."
- Meltzer, PC; Butler, D; Deschamps, JR; Madras, BK (2006). "1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogs. A promising class of monoamine uptake inhibitors". Journal of Medicinal Chemistry. 49 (4): 1420–32. doi:10.1021/jm050797a. PMC 2602954. PMID 16480278.
- Sauer, C.; Hoffmann, K.; Schimmel, U.; Peters, F. T. (2011). "Acute poisoning involving the pyrrolidinophenone-type designer drug 4′-methyl-alpha-pyrrolidinohexanophenone (MPHP)". Forensic Science International. 208 (1–3): e20–e25. doi:10.1016/j.forsciint.2011.02.026. PMID 21444164.
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