3',5'-cyclic-AMP phosphodiesterase

3',5'-cyclic-AMP phosphodiesterase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

3',5'-cyclic-AMP phosphodiesterase (EC, cAMP-specific phosphodiesterase, cAMP-specific PDE, PDE1, PDE2A, PDE2B, PDE4, PDE7, PDE8, PDEB1, PDEB2) is an enzyme with systematic name 3',5'-cyclic-AMP 5'-nucleotidohydrolase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction

adenosine 3',5'-cyclic phosphate + H2O AMP

This enzyme requires Mg2+ or Mn2+ for activity.


  1. Alonso, G.D.; Schoijet, A.C.; Torres, H.N.; Flawiá, M.M. (2006). "TcPDE4, a novel membrane-associated cAMP-specific phosphodiesterase from Trypanosoma cruzi". Mol. Biochem. Parasitol. 145 (1): 40–49. doi:10.1016/j.molbiopara.2005.09.005. PMID 16225937.
  2. Bader, S.; Kortholt, A.; Snippe, H.; Van Haastert, P.J. (2006). "DdPDE4, a novel cAMP-specific phosphodiesterase at the surface of Dictyostelium cells". J. Biol. Chem. 281 (29): 20018–20026. doi:10.1074/jbc.M600040200. PMID 16644729.
  3. Rascón, A.; Soderling, S.H.; Schaefer, J.B.; Beavo, J.A. (2002). "Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei". Proc. Natl. Acad. Sci. USA. 99 (7): 4714–4719. doi:10.1073/pnas.002031599. PMC 123713Freely accessible. PMID 11930017.
  4. Johner, A.; Kunz, S.; Linder, M.; Shakur, Y.; Seebeck, T. (2006). "Cyclic nucleotide specific phosphodiesterases of Leishmania major". BMC Microbiol. 6: #25–25. doi:10.1186/1471-2180-6-25. PMC 1431542Freely accessible. PMID 16522215.
  5. Lugnier, C.; Keravis, T.; Le Bec, A.; Pauvert, O.; Proteau, S.; Rousseau, E. (1999). "Characterization of cyclic nucleotide phosphodiesterase isoforms associated to isolated cardiac nuclei". Biochim. Biophys. Acta. 1472 (3): 431–446. doi:10.1016/S0304-4165(99)00145-2. PMID 10564757.
  6. Imamura, R.; Yamanaka, K.; Ogura, T.; Hiraga, S.; Fujita, N.; Ishihama, A.; Niki, H. (1996). "Identification of the cpdA gene encoding cyclic 3,5-adenosine monophosphate phosphodiesterase in Escherichia coli". J. Biol. Chem. 271 (41): 25423–25429. doi:10.1074/jbc.271.41.25423. PMID 8810311.

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