3,4-Methylenedioxypropiophenone

3,4-Methylenedioxypropiophenone

Names
Preferred IUPAC name 1-(2H-1,3-Benzodioxol-5-yl)propan-1-one
Other names 1-(Benzo[d][1,3]dioxol-5-yl)propan-1-one 1-(1,3-Benzodioxol-5-yl)-1-propanone 5-Propionyl-1,3-benzodioxole MDP1P
Identifiers
CAS Number	28281-49-4 Y
3D model (Jmol)	Interactive image
Beilstein Reference	165729
ChemSpider	86372 Y
ECHA InfoCard	100.044.473
EC Number	248-937-6
PubChem	95682
InChI InChI=1S/C10H10O3/c1-2-8(11)7-3-4-9-10(5-7)13-6-12-9/h3-5H,2,6H2,1H3 Y Key: RVBJGSPBFIUTTR-UHFFFAOYSA-N Y
SMILES CCC(=O)C1=CC2=C(C=C1)OCO2
Properties
Chemical formula	C10H10O3
Molar mass	178.19 g·mol−1
Density	1.21 g/mL
Melting point	37 °C (99 °F; 310 K)
Boiling point	166.5
Hazards
Safety data sheet	MSDS at Sigma Aldrich
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

3,4-Methylenedioxypropiophenone, also known as 3,4-(Methylenedioxy)phenyl-1-propanone (MDP1P), is a phenylpropanoid found in some plants of the genus Piper and is an isomer of 3,4-methylenedioxyphenyl-2-propanone (MDP2P).

Natural occurrence

Studies of various chemotypes of Piper marginatum have either detected this compound to be the dominate constituent of the plant's essential oil or absent from it altogether.^[1][2] Of 22 samples collected from South America, specimens from the following regions had the greatest amount of the chemical by dry leaf mass: Manaus (0.35%), Melgaço (0.348%), Belterra (0.33%), Monte Alegre (0.241 to 0.266%), and Alta Floresta (0.123%).^[2]

Uses

MDP1P is a can be used as a precursor in the synthesis of methylone and various other substituted methylenedioxy- phenethylamine derivatives. It can be prepared via a Grignard reaction between ethylmagnesium bromide and piperonylonitrile.

Legal status

United States

MDP1P is not a scheduled drug at the federal level in the United States nor is it on the DEA list of chemicals.^[3]

Florida

"3,4-methylenedioxy-propiophenone" along with "2-Bromo-3,4-Methylenedioxypropiophenone" and "3,4-methylenedioxy-propiophenone-2-oxime" are Schedule I controlled substances in the state of Florida making them illegal to buy, sell, or possess in Florida.^[4]

References