TFDP1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2AZE

Identifiers

Aliases

TFDP1, DP1, DRTF1, Dp-1, DILC, transcription factor Dp-1

External IDs

MGI: 101934 HomoloGene: 38276 GeneCards: TFDP1

Gene ontology
Molecular function	• DNA binding • protein domain specific binding • transcription factor activity, sequence-specific DNA binding • transcription coactivator activity • transcription factor binding • protein binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding
Cellular component	• transcription factor complex • nucleoplasm • nucleus • mitochondrion
Biological process	• regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • negative regulation of fat cell proliferation • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • cell cycle • cell proliferation • positive regulation of transcription from RNA polymerase II promoter • mitotic cell cycle • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • transcription, DNA-templated
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


7027


21781

Ensembl


ENSG00000198176


ENSMUSG00000038482

UniProt


Q14186


Q08639

RefSeq (mRNA)


NM_007111


NM_001291765 NM_001291766 NM_001291768 NM_009361

RefSeq (protein)


NP_009042.1


NP_001278694.1 NP_033387.1

Location (UCSC)

Chr 13: 113.58 – 113.64 Mb

Chr 8: 13.34 – 13.38 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Transcription factor Dp-1 is a protein that in humans is encoded by the TFDP1 gene.^[3]^[4]^[5]

Function

The E2F transcription factor family (see MIM 189971) regulates the expression of various cellular promoters, particularly those involved in the cell cycle. E2F factors bind to DNA as homodimers or heterodimers in association with dimerization partner DP1. TFDP1 may be the first example of a family of related transcription factors; see TFDP2 (MIM 602160).[supplied by OMIM]^[5]

Interactions

TFDP1 has been shown to interact with:

E2F1,^[6]^[7]^[8]^[9]
E2F5,^[6]^[10] and
P53.^[11]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Girling R, Partridge JF, Bandara LR, Burden N, Totty NF, Hsuan JJ, La Thangue NB (Nov 1993). "A new component of the transcription factor DRTF1/E2F". Nature. 365 (6445): 468. doi:10.1038/365468d0. PMID 8413592.
↑ Zhang Y, Venkatraj VS, Fischer SG, Warburton D, Chellappan SP (Mar 1997). "Genomic cloning and chromosomal assignment of the E2F dimerization partner TFDP gene family". Genomics. 39 (1): 95–8. doi:10.1006/geno.1996.4473. PMID 9027491.
1 2 "Entrez Gene: TFDP1 transcription factor Dp-1".
1 2 Sardet C, Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A, Weinberg RA (Mar 1995). "E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle". Proc. Natl. Acad. Sci. U.S.A. 92 (6): 2403–7. doi:10.1073/pnas.92.6.2403. PMC 42492. PMID 7892279.
↑ Suzuki M, Okuyama S, Okamoto S, Shirasuna K, Nakajima T, Hachiya T, Nojima H, Sekiya S, Oda K (Aug 1998). "A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer". Oncogene. 17 (7): 853–65. doi:10.1038/sj.onc.1202163. PMID 9780002.
↑ Wu CL, Zukerberg LR, Ngwu C, Harlow E, Lees JA (May 1995). "In vivo association of E2F and DP family proteins". Mol. Cell. Biol. 15 (5): 2536–46. doi:10.1128/mcb.15.5.2536. PMC 230484. PMID 7739537.
↑ Helin K, Wu CL, Fattaey AR, Lees JA, Dynlacht BD, Ngwu C, Harlow E (Oct 1993). "Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation". Genes Dev. 7 (10): 1850–61. doi:10.1101/gad.7.10.1850. PMID 8405995.
↑ Hijmans EM, Voorhoeve PM, Beijersbergen RL, van 't Veer LJ, Bernards R (Jun 1995). "E2F-5, a new E2F family member that interacts with p130 in vivo". Mol. Cell. Biol. 15 (6): 3082–9. doi:10.1128/mcb.15.6.3082. PMC 230539. PMID 7760804.
↑ Sørensen TS, Girling R, Lee CW, Gannon J, Bandara LR, La Thangue NB (Oct 1996). "Functional interaction between DP-1 and p53". Mol. Cell. Biol. 16 (10): 5888–95. doi:10.1128/mcb.16.10.5888. PMC 231590. PMID 8816502.

Wu CL, Zukerberg LR, Ngwu C, Harlow E, Lees JA (1995). "In vivo association of E2F and DP family proteins.". Mol. Cell. Biol. 15 (5): 2536–46. doi:10.1128/mcb.15.5.2536. PMC 230484. PMID 7739537.
Hijmans EM, Voorhoeve PM, Beijersbergen RL, van 't Veer LJ, Bernards R (1995). "E2F-5, a new E2F family member that interacts with p130 in vivo.". Mol. Cell. Biol. 15 (6): 3082–9. doi:10.1128/mcb.15.6.3082. PMC 230539. PMID 7760804.
Sardet C, Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A, Weinberg RA (1995). "E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle.". Proc. Natl. Acad. Sci. U.S.A. 92 (6): 2403–7. doi:10.1073/pnas.92.6.2403. PMC 42492. PMID 7892279.
Ginsberg D, Vairo G, Chittenden T, Xiao ZX, Xu G, Wydner KL, DeCaprio JA, Lawrence JB, Livingston DM (1994). "E2F-4, a new member of the E2F transcription factor family, interacts with p107.". Genes Dev. 8 (22): 2665–79. doi:10.1101/gad.8.22.2665. PMID 7958924.
Beijersbergen RL, Kerkhoven RM, Zhu L, Carlée L, Voorhoeve PM, Bernards R (1994). "E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo.". Genes Dev. 8 (22): 2680–90. doi:10.1101/gad.8.22.2680. PMID 7958925.
Bandara LR, Lam EW, Sørensen TS, Zamanian M, Girling R, La Thangue NB (1994). "DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein.". EMBO J. 13 (13): 3104–14. PMC 395201. PMID 8039504.
Helin K, Wu CL, Fattaey AR, Lees JA, Dynlacht BD, Ngwu C, Harlow E (1993). "Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation.". Genes Dev. 7 (10): 1850–61. doi:10.1101/gad.7.10.1850. PMID 8405995.
Rogers KT, Higgins PD, Milla MM, Phillips RS, Horowitz JM (1996). "DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo.". Proc. Natl. Acad. Sci. U.S.A. 93 (15): 7594–9. doi:10.1073/pnas.93.15.7594. PMC 38791. PMID 8755520.
Sørensen TS, Girling R, Lee CW, Gannon J, Bandara LR, La Thangue NB (1996). "Functional interaction between DP-1 and p53.". Mol. Cell. Biol. 16 (10): 5888–95. doi:10.1128/mcb.16.10.5888. PMC 231590. PMID 8816502.
Vidal M, Braun P, Chen E, Boeke JD, Harlow E (1996). "Genetic characterization of a mammalian protein-protein interaction domain by using a yeast reverse two-hybrid system.". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10321–6. doi:10.1073/pnas.93.19.10321. PMC 38382. PMID 8816798.
Magae J, Wu CL, Illenye S, Harlow E, Heintz NH (1997). "Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members.". J. Cell. Sci. 109. ( Pt 7): 1717–26. PMID 8832394.
Hofmann F, Livingston DM (1996). "Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit.". Genes Dev. 10 (7): 851–61. doi:10.1101/gad.10.7.851. PMID 8846921.
Trimarchi JM, Fairchild B, Verona R, Moberg K, Andon N, Lees JA (1998). "E2F-6, a member of the E2F family that can behave as a transcriptional repressor.". Proc. Natl. Acad. Sci. U.S.A. 95 (6): 2850–5. doi:10.1073/pnas.95.6.2850. PMC 19658. PMID 9501179.
Cartwright P, Müller H, Wagener C, Holm K, Helin K (1998). "E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription.". Oncogene. 17 (5): 611–23. doi:10.1038/sj.onc.1201975. PMID 9704927.
Timchenko NA, Wilde M, Darlington GJ (1999). "C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice.". Mol. Cell. Biol. 19 (4): 2936–45. PMC 84088. PMID 10082561.
Lam EW, Glassford J, van der Sman J, Banerji L, Pizzey AR, Shaun N, Thomas B, Klaus GG (1999). "Modulation of E2F activity in primary mouse B cells following stimulation via surface IgM and CD40 receptors.". Eur. J. Immunol. 29 (10): 3380–9. doi:10.1002/(SICI)1521-4141(199910)29:10<3380::AID-IMMU3380>3.0.CO;2-C. PMID 10540350.
Sansal I, Dupont E, Toru D, Evrard C, Rouget P (2000). "NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity.". Oncogene. 19 (43): 5000–9. doi:10.1038/sj.onc.1203843. PMID 11042687.
Hsu SI, Yang CM, Sim KG, Hentschel DM, O'Leary E, Bonventre JV (2001). "TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1.". EMBO J. 20 (9): 2273–85. doi:10.1093/emboj/20.9.2273. PMC 125435. PMID 11331592.

PDB gallery

2aze: Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer

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TFDP1

Function

Interactions

References

Further reading