Picornain 2A

Picornain 2A
Identifiers
EC number 3.4.22.29
CAS number 103406-62-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Picornain 2A (EC 3.4.22.29, picornavirus endopeptidase 2A, poliovirus protease 2A, rhinovirus protease 2A, 2A protease, 2A proteinase, protease 2A, proteinase 2Apro, picornaviral 2A proteinase, Y-G proteinase 2A, poliovirus proteinase 2A, poliovirus protease 2Apro) is an protease enzyme.[1][2][3] This enzyme catalyses the following chemical reaction:

Selective cleavage of Tyr-Gly bond in picornavirus polyprotein

This enzyme is coded by entero-, rhino-, aphto- and cardioviruses.

References

  1. Bazan, J.F.; Fletterick, R.J. (1988). "Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications". Proc. Natl. Acad. Sci. USA. 85: 7872–7876. doi:10.1073/pnas.85.21.7872. PMC 282299Freely accessible. PMID 3186696.
  2. König, H.; Rosenwirth, B. (1988). "Purification and partial characterization of poliovirus protease 2A by means of a functional assay". J. Virol. 62 (4): 1243–1250. PMID 2831385.
  3. Kräusslich H.-G.; Wimmer, E. (1988). "Viral proteinases". Annu. Rev. Biochem. 57: 701–754. doi:10.1146/annurev.bi.57.070188.003413. PMID 3052288.
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