4'-demethylrebeccamycin synthase

4'-demethylrebeccamycin synthase
Identifiers
EC number 4.3.3.5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

4'-demethylrebeccamycin synthase (EC 4.3.3.5, arcyriaflavin A N-glycosyltransferase, RebG) is an enzyme with systematic name 4'-demethylrebeccamycin D-glucose-lyase.[1][2] This enzyme catalyses the following chemical reaction

4'-O-demethylrebeccamycin + H2O dichloro-arcyriaflavin A + beta-D-glucose

This enzyme catalyses a step in the biosynthesis of rebeccamycin.

References

  1. Ohuchi, T.; Ikeda-Araki, A.; Watanabe-Sakamoto, A.; Kojiri, K.; Nagashima, M.; Okanishi, M.; Suda, H. (2000). "Cloning and expression of a gene encoding N-glycosyltransferase (ngt) from Saccharothrix aerocolonigenes ATCC39243". J. Antibiot. (Tokyo). 53 (4): 393–403. doi:10.7164/antibiotics.53.393. PMID 10866221.
  2. Zhang, C.; Albermann, C.; Fu, X.; Peters, N.R.; Chisholm, J.D.; Zhang, G.; Gilbert, E.J.; Wang, P.G.; Van Vranken, D.L.; Thorson, J.S. (2006). "RebG- and RebM-catalyzed indolocarbazole diversification". Chembiochem. 7: 795–804. doi:10.1002/cbic.200500504. PMID 16575939.

External links

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